The paleo-weathering crust is important for karst reservoir formation and hydrocarbon accumulation. Field geological survey reveals that there exists a paleo-weathering crust at the top of Sinian Dengying Formation in northern Guizhou Province, which was formed by Tongwan tectonic movement and is composed of yellowish brown scoriaceous clay rock. Its geochemistry is characterized by depletion of MgO and relative enrichment of SiO2, Al2O3, Fe2O3, Fe2O, P2O5, and TiO2. The paleo-weathering crust is somewhat different in different facies, which results in the difference of underlying karst reservoirs.