The South Lake Area of the MinqinBasin is a typical area for examining stress on groundwater resources in the GobiDesert using hydrogeological and hydrochemical methods. The objectives of this study are to determine the relationship between regional structural elements and the hydrochemical evolution of groundwater in the southwest part of the TenggerDesert. The geochemical inverse model confirmed that the proposed water-rock interactions can occur in this system. The chemical composition of the water is strongly influenced by evaporation of shallow groundwater and subsequent dissolution of halite and gypsum during recharge in the rainy season, as determined by ionic plots and saturation index.