This paper studied the regional characteristics of metallogenesis and structural evolution phases of Yunkai area in Guangxi, and compared with the properties such as ore-control geological factors, mineralization epoch, material sources, which come from the chosen main deposits. Regional mineralization modes were summarized based on typical deposits forming modes. As a result, the regional metallogenetic epochs are Caledonian, Varisco-Indonsinian, Yanshannian, and those are more cognition in the ore-forming condition in the area. The study of regional mineral genetic regularity is great significance for guiding the estimate of regional mines and deploying the ore prospecting work.