LITHOPROBE is Canada’s national earth science program. Ten typical sections representing to some extents the typical geological characteristics of Canada or major tectonic processes have global significance. In terms of time, its geological evolution covers more than 4 Ga across the long geological age. A series of achievements have been made results using deep seismic reflection technology and comprehensive study of various disciplines. This paper intends to systematically introduce LITHOPROBE in the hope to provide references for China’s deep exploration technology and experiment research.