In the light of genetic sequence stratigraphy, this paper deals with sequence filling and New Tethys evolution of Qum Formation in central IranBasin. The authors suggest that this basin possesses typical composite characteristics of superposition in vertical direction and complexity in horizontal direction. Its formation and evolution were controlled by both the tensile force from Tethys and the converging force from Arabic and Iranian plates and underwent orogenic rifting (Z1); passive continental margin (Z2-T2); rifting basin (T3); back-arc foreland basin (J-N11); and intracontinental depression and reworking (N12-Q) stages. The filling process formed the four sedimentary sequences of S1, S2, S3 and S4 and experienced four sea level events, namely, Chattian, early Aquitanian, late Aquitanian and Burdigalian stages.